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Major Depressive Disorder Q&A


What is a major depressive disorder?

Major depressive disorder is a mental health condition that requires treatment. It’s diagnosed when you experience extreme sadness or hopelessness that causes difficulty with daily function. 

Everyone experiences moments of sadness in their lives, usually in response to a stressful or painful event. Major depressive disorder, however, causes sadness that’s crippling when left untreated. 

The condition also puts you at risk of developing physical health problems, like coronary artery disease and substance abuse disorders.

Who struggles with major depressive disorder?

At least 21 million adults in the United States have had one or more major depressive episodes. Women are more likely than men to experience a major depressive disorder. A major depressive disorder often strikes in early adulthood. It can run in families, too. 

Factors that contribute to the development of major depressive disorder include: 

  • Hormone fluctuations
  • Certain personality traits
  • Having additional mental health conditions
  • Debilitating medical problems 
  • Traumatic or stressful life events
  • Alcohol or drug abuse

Chronic disease, job loss, financial difficulties, divorce, or a death in the family can also trigger a major depressive disorder in vulnerable people.

What are the symptoms of a major depressive disorder?

The primary symptoms of a major depressive disorder include:

  • Debilitating or ongoing sadness
  • Loss of interest in favorite activities
  • Feeling hopeless, worthless, guilty, or shameful
  • Sleeping problems
  • Irritability and mood swings
  • Weight loss or gain
  • Appetite changes
  • Thoughts of suicide
  • Fatigue
  • Physical aches and pains
  • Drug or alcohol abuse

Untreated major depressive disorder can affect your daily interactions and impact your school, work, and relationships. 

What are the treatments for major depressive disorder?

Medications and counseling help patients manage their depression. At Precise Research Centers, the clinical team oversees trials for the latest medications that treat a major depressive disorder. 

The team is available to provide support when you’re going through a clinical trial. Staff members listen and offer strategies for behavioral changes to help you manage depression.

If you’ve been diagnosed with major depressive disorder or are currently experiencing depression, contact Precise Research Centers to learn more about the clinical trials available. Call the office or fill out the online form on this website.